Cleft Lip and Cleft Palate
March of Dimes, 2007
"... detailed overview of CL/P ... "

Folic Acid May Prevent Cleft Lip and Palate
Robin Macker, US Department of Health and Human Services, January 26, 2007
"... evidemce for the use of Folic acid to reduce the risk of CL/P ... "

Cleft Lip and Palate
Medline Plus, US National Library of Medicine, May 31, 2007
"... excellent web page for all types of people ... great site to send parents to ..."

Cleft Lip or Palate
American Society of Plastic Surgeons, 2007
"... overview of the surgical procedures to correct CL/P as well as the risk associated with the procedure ... addresses parents' needs ..."

Cleft Lip and Palate
Barbara P. Homeier, MD, The Nemours Foundation, September 2005
"... great starter site for parents ..."

Closing in on Clefting
NIDCR
[for Professionals mainly]
The varied array of clefting syndromes - the failure of the lip or palate to fuse properly … Cleft lip with or without cleft palate ( CL / P ) … NIDCR grantees have mapped the gene for Van der Woude syndrome, the most common form of syndromic clefting, to a narrow band on chromosome 1. However, the genes for non-syndromic clefting have been more elusive targets … In human studies, CL/P has been associated with genes on several different chromosomes … There are associations with specific regions on chromosomes 4, 6, and 19 that contain both know and unknown genes … Less is known about the underlying causes of cleft palate ( CP ) as an independent disorder. Scientists are closing in on the gene for a form of CP transmitted on the X chromosome ...

Cleft Palate, Isolated; CPI
Victor A. McKusick, OMIM, Johns Hopkins University, 2007
[for Professionals mainly]
Alternative titles; symbols
CLEFT PALATE; CP
CLEFT PALATE, ISOLATED
Gene Map Locus: 2q32
Cleft palate as an isolated malformation behaves as an entity distinct from cleft lip with or without cleft palate estimated that the risk of recurrence in subsequently born children is about 2% if 1 child has it, 6% if 1 parent has it, and 15% if 1 parent and 1 child have it … The genetics is apparently complex … 2 classes of non-syndromic cleft palate: (1) familial CP, which appears to have an autosomal dominant component to its etiology, and (2) non-familial CP, which, by demonstrating an increasing frequency of CP with time and a maternal age effect, appears to be related to environmental factors ...

Orofacial Cleft 1
Victor A. McKusick, OMIM, Johns Hopkins University, 2007
[for Professionals mainly]
Alternative titles; symbols
CLEFT LIP WITH OR WITHOUT CLEFT PALATE
OROFACIAL CLEFT, NONSYNDROMIC; OFC
Gene Map Locus: 6p24.3
Over 200 syndromes, including a number that are either chromosomal or mendelian in causation, have cleft lip and/or palate as feature(s) Gorlin, 1982 ...

Orofacial Cleft 2; OFC2
Victor A. McKusick, OMIM, Johns Hopkins University, 2007
[for Professionals mainly]
38 non - syndromic orofacial cleft families of Italian ancestry from northeastern regions of Italy were studied for linkage to 2p13 … The same collection of families had been used to demonstrate linkage to the 6p23 chromosome region, with the presence of genetic heterogeneity … Evidence for genetic heterogeneity in this family set was apparently by both pairwise and multipoint linkage analyses ...

Feeding Equipment and Advice
CLAPA ( Cleft Lip and Palate Association ), February 8, 2000
[Support Group]
This page is designed as a guide to some of the ways that your baby may be helped with feeding …
Ways of helping may include:
A different approach to breast feeding.
A different shaped teat with enlarged or newly positioned holes.
A different bottle for bottle feeding, e.g. a soft squeezy bottle to help the flow of milk or a bottle with a scoop attached, which requires less effort if the baby has not got the energy to suck from a teat.
A thin feeding tube may be passed into the stomach through the nose or mouth to help those babies initially who also have a small jaw ...

The Craniofacial Foundation of America
Tennessee Craniofacial Center
[Support Group]
Craniofacial Foundation of America ( CFA ) support the work of the Tennessee Craniofacial Center in Chattanooga while offering a variety of services for patients and health professionals. Services provided by the CFA may include: Direct financial aid for non medical expenses for qualified patients traveling to the Tennessee Craniofacial Center - a facility that regularly attracts patients from throughout the United States ...

Velocardiofacial Syndrome
Victor A. McKusick, OMIM, Johns Hopkins University, 2007
[for Professionals mainly]
Alternative titles; symbols
VCF SYNDROME; VCFS
SHPRINTZEN VCF SYNDROME
Shprintzen et al. (1981) reported on 39 patients with a syndrome characterized by the following frequent features: cleft palate, cardiac anomalies, typical facies, and learning disabilities. Less frequent features included microcephaly, mental retardation, short stature, slender hands and digits, minor auricular anomalies, and inguinal hernia. The Pierre Robin syndrome was present in 4. The heart malformation was most often ventricular septal defect. In the group studied, mother and daughter were affected in 2 instances, mother and son in 1, and mother and both daughter and son in 1 ... Goldberg et al. (1993) reviewed the full spectrum of the velocardiofacial syndrome on the basis of 120 patients. Learning disability, cleft palate, and pharyngeal hypotonia were present in 90% or more of the patients; cardiac anomalies in 82%; slender hands and digits in 63%; medial displacement of internal carotid arteries in 25%; umbilical hernia in 23%; and hypospadias in 10% of males. Shprintzen et al. (1992) pointed out that psychotic illness is also a feature of VCFS in adolescents or adults. In this connection, Dunham et al. (1992) pointed out that the HP500 sequence often deleted in VCFS is located within the same 450-kb yeast artificial chromosome (YAC) as the catechol-O-methyltransferase (COMT; 116790) gene, which might, therefore, be deleted also in this disorder. Deletion of COMT might have a causative relationship to psychotic illness … Golding-Kushner et al. (1985) observed that children with VCFS had 'characteristic personality features,' which were described as blunt or inappropriate affect, and that a greater than expected number of these children developed severe psychiatric illnesses as they approached adolescence … schizophrenic phenotype in VCFS patients ...

CLEFT LIP
Victor A. McKusick, OMIM, Johns Hopkins University, 2007
[for Professionals mainly]
Alternative titles; symbols
CONGENITAL HEALED CLEFT LIP; CHCL
Congenital 'healed' cleft lip (CHCL) is an unusual anomaly consisting of a paramedian 'scar' of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero. The CHCL is frequently associated with an ipsilateral notch in the vermilion border and a 'collapsed' nostril. Castilla and Martinez-Frias (1995) presented 25 CHCL cases

Dental care for the patient with a cleft lip and palate. Part 2
C. J. Rivkin, et al. BDJ ( British Dental Journal ), Volume 188, No. 3, February 12, 2000 …
[for Professionals mainly]
Part 2 looks at dental care from the mixed dentition stage through to adolescence and young adulthood …
In brief:
The patient is encouraged to start accepting responsibility for his or her own dental health with prevention playing a key role.
Teasing at school can be a problem.
Patience, support and skillful behaviour management are important.
Patient motivation can decrease in the teenage years. Multiple visits for cleft-related care are a factor.
Good communication with the cleft team is essential. Dental extraction should be carried out only after consultation with the orthodontist involved with cleft care ...

Children's Craniofacial Association
Children's Craniofacial Association, 2007
[Support Group]
A national, nonprofit organization, headquartered in Dallas, Texas, dedicated to improving the quality of life for facially disfigured individuals and their families ...

CLAPA Cleft Lip and Palate Association
CLAPA, 2007
[Support Group]
One in every 600-700 children in the UK is born with a cleft of the lip or the palate … This web site attempts to answer some of the most commonly - asked questions about cleft lip and palate and provides information on the services and advice offered by CLAPA ...

Overview of Cleft Lip & Palate Management
Smiles Org.
A child born with cleft lip and/or palate can have great difficulty making this adjustment … May have multiple problems which require different specialists … The health care providers who frequently participate in a cleft palate team include:
Audiologist
Ear, Nose, Throat surgeon
Geneticist
Neurosurgeon
Nurse
Pediatric dentist, Orthodontist / Prosthodontist / Maxillofacial surgeon
Pediatrician
Plastic surgeon
Social worker / Psychologist
Speech and language pathologist ...

Cleft lip & palate
Prescription Parents, Inc.

Cleft Lip and Palate Resource
Wide Smiles Inc, December 29, 2006
Together we share the struggle, the pain, the joy and the triumph of watching our children grow. Their challenges may be many, but we can face them together, learn from each other and help our children to recognize their beauty within ...

Cleft Palate Foundation (Illustrated)
Cleft Palate Foundation, 2006
Do you know about the fourth most common birth defect?
It's cleft lip and palate
A cleft lip is a separation of the two sides of the lip ... Clefts of the lip may occur on one or both sides ... Figure 2 illustrates a normal palate and labels of the palate ...
Because the lip and the palate develop separately, it is possible for the child to have a cleft lip, a cleft palate, or both cleft lip and palate ...
Cleft lip and palate are congenital or birth detects which occur very early in pregnancy ... Children born with a cleft frequently require a number of different types of services. e.g., surgery, dental / orthodontic care and speech therapy, which need to be provided in a coordinated manner over a period of years ...

Facial Differences Information and Support Network
Let's Face It, October 16, 2006
Contains organizations and resources that focus on the many aspects of facial disfigurement ...

Smiles - Welcome
SMILES, May 31, 2006
"SMILES" is a group of dedicated families who have developed a first-hand understanding of the needs of children with cleft lip, cleft palate and craniofacial deformities. Through our personal sensitivity, energy, knowledge, and love we are dedicated to improve the lives of these children in our country and around the world ...

OperationSmile
Operation Smile, June 4, 2007
Operation Smile is the not-for-profit, volunteer medical services organization that provides reconstructive facial surgery to indigent children and young adults in 16 developing countries and in the United States ...

Labio Leporino y Paladar Hendido
University of Virginia Health System, January 28, 2008
[Illustrated] [Spanish]
¿Qué son el labio leporino y el paladar hendido? ... El labio leporino y el paladar hendido son anomalías de nacimiento de la boca y del labio. El labio leporino y el paladar hendido  son los cuarto más común de defectos de nacimiento en los estados unidos y afecta a aproximadamente uno de cada 700 nacimientos por año. Estas malformaciones son menos frecuentes en la población afroamericana. El labio leporino y el paladar hendido se desarrollan en la etapa temprana del embarazo, cuando los lados del labio y del paladar no se fusionan como deberían. Un niño puede tener labio leporino, paladar hendido o ambos. El labio leporino y el paladar hendido juntos son más comunes en los niños que en las niñas. Es también importante saber que la mayoría de los bebés que nacen con una hendidura son sanos y no tienen ninguna otra anomalía congénita ...

Oral Facial Clefts
I.B.I.S. Birth Defects, February 5, 2002
[For Parents] [Ukrainian]
Ukrainian factsheet for parents

Cleft Lip and Palate
I.B.I.S. Birth Defects, February 15, 2002
[Ukrainian]
Factsheet in Ukrainian

Folic Acid and Prevention of Oral Clefts
I.B.I.S. Birth Defects, January 22, 2004
[Ukrainian]
Factsheet in Ukrainian

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Last Updated: 2008/3/3

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